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Painkiller shots were a piece of evidence in Apollo Justice's investigation into the murder of Khura'inese Minister of Justice Inga Karkhuul Khura'in. Inga regularly used them on himself due to his chronic back pain.
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After Inga's murder via a stab wound to the back, Apollo Justice attempted to use the painkiller in court as evidence to suggest that he might not have noticed the stabbing immediately due to the medicine's effect. However, a later Divination Séance proved that this theory was incorrect.